Open AccessQTL MatchMaker: a multi-species quantitative trait loci (QTL) database and query system for annotation of genes and QTL
Author(s) -
Kremena V. Star,
Quingbin Song,
Andy Z.X. Zhu,
Erwin P. Böttinger
Publication year - 2006
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkj027
Subject(s) - quantitative trait locus , biology , family based qtl mapping , genome , genomics , genetics , context (archaeology) , annotation , gene , computational biology , gene annotation , candidate gene , gene mapping , paleontology , chromosome
Identifying genes that underlie quantitative trait loci (QTL) is a challenging task. Here, we present a new QTL software system, named QTL MatchMaker. The system is designed to integrate and mine QTL information across human, mouse and rat genomes and to annotate functional genomic data. It combines and organizes information from relevant public databases and publications and integrates QTL, physical, genetic and cytogenetic maps across human, mouse and rat. To make this application available to the research community we have developed a website for high-throughput mapping of expressed sequences to QTL and for selection of candidate genes in the physiological genomics context of complex traits. QTL MatchMaker is accessible at http://pmrc.med.mssm.edu:9090/QTL/jsp/qtlhome.jsp.