A study on the correlation of nucleotide skews and the positioning of the origin of replication: different modes of replication in bacterial species | Zendy

Christoforos Nikolaou | Zendy

Open Access

A study on the correlation of nucleotide skews and the positioning of the origin of replication: different modes of replication in bacterial species

Author(s) -

Christoforos Nikolaou

Publication year - 2005

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gki988

Subject(s) - biology , origin of replication , genetics , replication (statistics) , dna replication , genome , origin recognition complex , replication timing , transcription (linguistics) , archaea , dna , gene , eukaryotic dna replication , virology , linguistics , philosophy

Deviations from Chargaff's 2nd parity rule, according to which A approximately T and G approximately C in single stranded DNA, have been associated with replication as well as with transcription in prokaryotes. Based on observations regarding mainly the transcription-replication co-linearity in a large number of prokaryotic species, we formulate the hypothesis that the replication procedure may follow different modes between genomes throughout which the skews clearly follow different patterns. We draw the conclusion that multiple functional sites of origin of replication may exist in the genomes of most archaea and in some exceptional cases of eubacteria, while in the majority of eubacteria, replication occurs through a single fixed origin.

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