GENSTYLE: exploration and analysis of DNA sequences with genomic signature | Zendy

Bernard Fertil | Zendy; M Massin | Zendy; Sylvain Lespinats | Zendy; Clément Devic | Zendy; Ph. Dumée | Zendy; Alain Giron | Zendy

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GENSTYLE: exploration and analysis of DNA sequences with genomic signature

Author(s) -

Bernard Fertil,

M Massin,

Sylvain Lespinats,

Clément Devic,

Ph. Dumée,

Alain Giron

Publication year - 2005

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gki489

Subject(s) - biology , genbank , computational biology , genome , genetics , phylogenetics , dna sequencing , genomic dna , oligonucleotide , evolutionary biology , dna , gene

GENSTYLE (http://Genstyle.imed.jussieu.fr) is a workspace designed for the characterization and classification of nucleotide sequences. Based on the genomic signature paradigm, GENSTYLE focuses on oligonucleotide frequencies in DNA sequences. Users can select sequences of interest in the GENSTYLE companion database, where the whole set of GenBank sequences is grouped per species, or upload their own sequences to work with. Tools for the exploration and analysis of signatures allow (i) identification of the origin of DNA segments (detection of rare species or species for which technical problems prevent fast characterization, such as micro-organisms with slow growth), (ii) analysis of the homogeneity of a genome and isolation of areas with novel functionality (horizontal transfers for example)--and (iii) molecular phylogeny and taxonomy.

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