GenePath: from mutations to genetic networks and back | Zendy

Peter Juvan | Zendy; Janez Demšar | Zendy; Gad Shaulsky | Zendy; Blaž Zupan | Zendy

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GenePath: from mutations to genetic networks and back

Author(s) -

Peter Juvan,

Janez Demšar,

Gad Shaulsky,

Blaž Zupan

Publication year - 2005

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gki426

Subject(s) - biology , dictyostelium discoideum , key (lock) , computational biology , mutation , genetics , mutant , gene , ecology

GenePath is a web-based application for the analysis of mutant-based experiments and synthesis of genetic networks. Here, we introduce GenePath and describe a number of new approaches, including conflict resolution, handling cyclic pathways, confidence level assignment, what-if analysis and new experiment proposal. We illustrate the key concepts using data from a study of adhesion genes in Dictyostelium discoideum and show that GenePath discovered genetic interactions that were ignored in the original publication. GenePath is available at http://www.genepath.org/genepath2.

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