The ProDom database of protein domain families: more emphasis on 3D | Zendy

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The ProDom database of protein domain families: more emphasis on 3D

Author(s) -

C. Bru

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gki034

Subject(s) - biology , structural genomics , protein domain , inference , visualization , database , domain (mathematical analysis) , web server , interface (matter) , computational biology , genomics , selection (genetic algorithm) , protein structure database , homology (biology) , bioinformatics , the internet , genome , protein structure , computer science , genetics , data mining , world wide web , sequence database , gene , artificial intelligence , mathematical analysis , pulmonary surfactant , biochemistry , gibbs isotherm , mathematics

ProDom is a comprehensive database of protein domain families generated from the global comparison of all available protein sequences. Recent improvements include the use of three-dimensional (3D) information from the SCOP database; a completely redesigned web interface (http://www.toulouse.inra.fr/prodom.html); visualization of ProDom domains on 3D structures; coupling of ProDom analysis with the Geno3D homology modelling server; Bayesian inference of evolutionary scenarios for ProDom families. In addition, we have developed ProDom-SG, a ProDom-based server dedicated to the selection of candidate proteins for structural genomics.

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