The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis | Zendy

Frances M. G. Pearl | Zendy; Annabel E. Todd | Zendy; Ian Sillitoe | Zendy; Mark Dibley | Zendy; Oliver Redfern | Zendy; Tony E. Lewis | Zendy; Christopher Bennett | Zendy; Russell L. Marsden | Zendy; Alastair Grant | Zendy; David Lee | Zendy; Adrian Akpor | Zendy; Michael Maibaum | Zendy; Andrew Harrison | Zendy; Timothy J. Dallman | Zendy; Gabrielle A. Reeves | Zendy; Ilhem Diboun | Zendy; Sarah Addou | Zendy; Stefano Lise | Zendy; Caroline Johnston | Zendy; Antonio Sillero | Zendy; Janet M. Thornton | Zendy; Christine Orengo | Zendy

Open Access

The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis

Author(s) -

Frances M. G. Pearl,

Annabel E. Todd,

Ian Sillitoe,

Mark Dibley,

Oliver Redfern,

Tony E. Lewis,

Christopher Bennett,

Russell L. Marsden,

Alastair Grant,

David Lee,

Adrian Akpor,

Michael Maibaum,

Andrew Harrison,

Timothy J. Dallman,

Gabrielle A. Reeves,

Ilhem Diboun,

Sarah Addou,

Stefano Lise,

Caroline Johnston,

Antonio Sillero,

Janet M. Thornton,

Christine Orengo

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gki024

Subject(s) - genbank , biology , sequence (biology) , sequence alignment , sequence database , sequence analysis , uniprot , genome , genetics , computational biology , bioinformatics , database , computer science , peptide sequence , gene

The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath/) currently contains 43,229 domains classified into 1467 superfamilies and 5107 sequence families. Each structural family is expanded with sequence relatives from GenBank and completed genomes, using a variety of efficient sequence search protocols and reliable thresholds. This extended CATH protein family database contains 616,470 domain sequences classified into 23,876 sequence families. This results in the significant expansion of the CATH HMM model library to include models built from the CATH sequence relatives, giving a 10% increase in coverage for detecting remote homologues. An improved Dictionary of Homologous superfamilies (DHS) (http://www.biochem.ucl.ac.uk/bsm/dhs/) containing specific sequence, structural and functional information for each superfamily in CATH considerably assists manual validation of homologues. Information on sequence relatives in CATH superfamilies, GenBank and completed genomes is presented in the CATH associated DHS and Gene3D resources. Domain partnership information can be obtained from Gene3D (http://www.biochem.ucl.ac.uk/bsm/cath/Gene3D/). A new CATH server has been implemented (http://www.biochem.ucl.ac.uk/cgi-bin/cath/CathServer.pl) providing automatic classification of newly determined sequences and structures using a suite of rapid sequence and structure comparison methods. The statistical significance of matches is assessed and links are provided to the putative superfamily or fold group to which the query sequence or structure is assigned.

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