Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation | Zendy

P. Christoph Champ | Zendy; Sandor Maurice | Zendy; J.M. Vargason | Zendy; Tracy Camp | Zendy; P Shing Ho | Zendy

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Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation

Author(s) -

P. Christoph Champ,

Sandor Maurice,

J.M. Vargason,

Tracy Camp,

P Shing Ho

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh988

Subject(s) - biology , gene , genetics , dna , transcription factor , human genome , chromosome , nucleosome , promoter , transcriptional regulation , regulation of gene expression , microbiology and biotechnology , gene expression , histone , genome

An analysis of the human chromosome 22 genomic sequence shows that both Z-DNA forming regions (ZDRs) and promoter sites for nuclear factor-I (NFI) are correlated with the locations of known and predicted genes across the chromosome and accumulate around the transcriptional start sites of the known genes. Thus, the occurrence of Z-DNA across human genomic sequences mirrors that of a known eukaryotic transcription factor. In addition, 43 of the 383 fully annotated chromosomal genes have ZDRs within 2 nucleosomes upstream of strong NFIs. This suggests a distinct class of human genes that may potentially be transcriptionally regulated by a mechanism that couples Z-DNA with NFI activation, similar to the mechanism previously elucidated for the human colony stimulation factor-I promoter [Liu et al. (2001) Cell, 106, 309-318]. The results from this study will facilitate the design of experimental studies to test the generality of this mechanism for other genes in the cell.

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