The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences | Zendy

Wolfgang Helmberg | Zendy; Raymond Dunivin | Zendy; Michael Feolo | Zendy

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The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences

Author(s) -

Wolfgang Helmberg,

Raymond Dunivin,

Michael Feolo

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh424

Subject(s) - biology , typing , genetics , allele , human leukocyte antigen , gene , major histocompatibility complex , computational biology , ploidy , antigen

The dbMHC resource (http://www.ncbi.nlm.nih.gov/mhc/sbt.cgi?cmd=main) at the National Center for Biotechnology Information (NCBI) has developed an online tool for evaluating the allelic composition of sequencing-based typing (SBT) results of cDNA or genomic sequences. Whether the samples are heterozygous, haploid or a combination of the two, they can be compared with two up-to-date databases of all known alleles of several human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) loci. The results of the submission are returned as a table of potential allele hits, along with the respective base changes and an interactive sequence viewer for close examination of the alignment.

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