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CARNAC: folding families of related RNAs
Author(s) -
Hélène Touzet,
Olivier Perriquet
Publication year - 2004
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkh415
Subject(s) - biology , rnase p , computational biology , rna , rnase h , genetics , small nucleolar rna , protein secondary structure , nucleic acid secondary structure , folding (dsp implementation) , sequence (biology) , web server , similarity (geometry) , sequence alignment , bioinformatics , non coding rna , peptide sequence , the internet , gene , computer science , artificial intelligence , biochemistry , world wide web , electrical engineering , image (mathematics) , engineering
We present a tool for the prediction of conserved secondary structure elements of a family of homologous non-coding RNAs. Our method does not require any prior multiple sequence alignment. Thus, it successfully applies to datasets with low primary structure similarity. The functionality is demonstrated using three example datasets: sequences of RNase P RNAs, ciliate telomerases and enterovirus messenger RNAs. CARNAC has a web server that can be accessed at the URL http://bioinfo.lifl.fr/carnac.

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