SDPMOD: an automated comparative modeling server for small disulfide-bonded proteins | Zendy

Lesheng Kong | Zendy; B. T. K. Lee | Zendy; J. Tong | Zendy; Tin Wee Tan | Zendy; Shoba Ranganathan | Zendy

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SDPMOD: an automated comparative modeling server for small disulfide-bonded proteins

Author(s) -

Lesheng Kong,

B. T. K. Lee,

J. Tong,

Tin Wee Tan,

Shoba Ranganathan

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh394

Subject(s) - template , personalization , biology , selection (genetic algorithm) , computer science , computational biology , interface (matter) , process (computing) , service (business) , web service , bioinformatics , world wide web , biochemistry , programming language , machine learning , economy , economics , pulmonary surfactant , gibbs isotherm

Small disulfide-bonded proteins (SDPs) are rich sources for therapeutic drugs. Designing drugs from these proteins requires three-dimensional structural information, which is only available for a subset of these proteins. SDPMOD addresses this deficit in structural information by providing a freely available automated comparative modeling service to the research community. For expert users, SDPMOD offers a manual mode that permits the selection of a desired template as well as a semi-automated mode that allows users to select the template from a suggested list. Besides the selection of templates, expert users can edit the target-template alignment, thus allowing further customization of the modeling process. Furthermore, the web service provides model stereochemical quality evaluation using PROCHECK. SDPMOD is freely accessible to academic users via the web interface at http://proline.bic.nus.edu.sg/sdpmod.

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