GlycoFragment and GlycoSearchMS: web tools to support the interpretation of mass spectra of complex carbohydrates | Zendy

Klaus Karl Lohmann | Zendy; C.-W. von der Lieth | Zendy

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GlycoFragment and GlycoSearchMS: web tools to support the interpretation of mass spectra of complex carbohydrates

Author(s) -

Klaus Karl Lohmann,

C.-W. von der Lieth

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh392

Subject(s) - mass spectrum , biology , interpretation (philosophy) , spectral line , identification (biology) , biological system , mass spectrometry , glycan , matching (statistics) , computational biology , computer science , physics , mathematics , chromatography , chemistry , statistics , botany , genetics , programming language , astronomy , glycoprotein

In recent years, mass spectrometry has become the method of choice for high-sensitivity glycan identification. Currently, only a few tools assisting mass spectra interpretation are available. The web application GlycoFragment (www.dkfz.de/spec/projekte/fragments/) calculates all theoretically possible fragments of complex carbohydrates and aims to support the interpretation of mass spectra. GlycoSearchMS (www.dkfz.de/spec/glycosciences.de/sweetdb/ms/) compares each peak of a measured mass spectrum with the calculated fragments of all structures contained in the SweetDB database. The best-matching spectra and the associated structures are displayed in order of decreasing similarity. Since both algorithms work very efficiently, they are well suited to be used for automatic identification of series of mass spectra of complex carbohydrates.

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