AUGUSTUS: a web server for gene finding in eukaryotes | Zendy

Mario Stanke | Zendy; Ralph Steinkamp | Zendy; Stephan Waack | Zendy; Burkhard Morgenstern | Zendy

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AUGUSTUS: a web server for gene finding in eukaryotes

Author(s) -

Mario Stanke,

Ralph Steinkamp,

Stephan Waack,

Burkhard Morgenstern

Publication year - 2004

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh379

Subject(s) - biology , web server , intron , gene , computational biology , sequence (biology) , hidden markov model , genetics , drosophila melanogaster , software , gene prediction , genome , computer science , artificial intelligence , the internet , world wide web , programming language

We present a www server for AUGUSTUS, a novel software program for ab initio gene prediction in eukaryotic genomic sequences. Our method is based on a generalized Hidden Markov Model with a new method for modeling the intron length distribution. This method allows approximation of the true intron length distribution more accurately than do existing programs. For genomic sequence data from human and Drosophila melanogaster, the accuracy of AUGUSTUS is superior to existing gene-finding approaches. The advantage of our program becomes apparent especially for larger input sequences containing more than one gene. The server is available at http://augustus.gobics.de.

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