MitoProteome: mitochondrial protein sequence database and annotation system | Zendy

Dawn Cotter | Zendy; Purnima Guda | Zendy; Eoin Fahy | Zendy; Shankar Subramaniam | Zendy

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MitoProteome: mitochondrial protein sequence database and annotation system

Author(s) -

Dawn Cotter,

Purnima Guda,

Eoin Fahy,

Shankar Subramaniam

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh048

Subject(s) - ensembl , sequence database , biology , annotation , database , protein structure database , protein data bank (rcsb pdb) , uniprot , protein sequencing , human protein atlas , computational biology , relational database , protein domain , protein family , information retrieval , bioinformatics , peptide sequence , genetics , genome , genomics , gene , computer science , biochemistry , protein expression

MitoProteome is an object-relational mitochondrial protein sequence database and annotation system. The initial release contains 847 human mitochondrial protein sequences, derived from public sequence databases and mass spectrometric analysis of highly purified human heart mitochondria. Each sequence is manually annotated with primary function, subfunction and subcellular location, and extensively annotated in an automated process with data extracted from external databases, including gene information from LocusLink and Ensembl; disease information from OMIM; protein-protein interaction data from MINT and DIP; functional domain information from Pfam; protein fingerprints from PRINTS; protein family and family-specific signatures from InterPro; structure data from PDB; mutation data from PMD; BLAST homology data from NCBI NR; and proteins found to be related based on LocusLink and SWISS-PROT references and sequence and taxonomy data. By highly automating the processes of maintaining the MitoProteome Protein List and extracting relevant data from external databases, we are able to present a dynamic database, updated frequently to reflect changes in public resources. The MitoProteome database is publicly available at http://www. mitoproteome.org/. Users may browse and search MitoProteome, and access a complete compilation of data relevant to each protein of interest, cross-linked to external databases.

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