The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms | Zendy

Liam J. McGuffin | Zendy

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The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms

Author(s) -

Liam J. McGuffin

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh043

Subject(s) - biology , genome , threading (protein sequence) , annotation , computational biology , structural genomics , relational database , genome browser , database , genomics , gene , genetics , protein structure , computer science , biochemistry

Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The Gen THREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.

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