SCOP database in 2004: refinements integrate structure and sequence family data | Zendy

Antonina Andreeva | Zendy; Dave Howorth | Zendy; Steven E. Brenner | Zendy; Tim Hubbard | Zendy; C. Chothia | Zendy; Alexey G. Murzin | Zendy

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SCOP database in 2004: refinements integrate structure and sequence family data

Author(s) -

Antonina Andreeva,

Dave Howorth,

Steven E. Brenner,

Tim Hubbard,

C. Chothia,

Alexey G. Murzin

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh039

Subject(s) - structural classification of proteins database , biology , sequence (biology) , protein family , set (abstract data type) , domain (mathematical analysis) , database , computational biology , protein data bank , protein domain , sequence alignment , sequence database , repertoire , protein structure database , interface (matter) , protein structure , computer science , peptide sequence , genetics , biochemistry , gene , mathematical analysis , pulmonary surfactant , gibbs isotherm , physics , mathematics , acoustics , programming language

The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides important information for understanding the protein world and its evolutionary repertoire. SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. As part of this project, starting with release 1.63, we have initiated a refinement of the SCOP classification, which introduces a number of changes mostly at the levels below superfamily. The pending SCOP reclassification will be carried out gradually through a number of future releases. In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.

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