JASPAR: an open-access database for eukaryotic transcription factor binding profiles | Zendy

Albin Sandelin | Zendy; Wynand Alkema | Zendy; Pär G. Engström | Zendy; Wyeth W. Wasserman | Zendy; Boris Lenhard | Zendy

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JASPAR: an open-access database for eukaryotic transcription factor binding profiles

Author(s) -

Albin Sandelin,

Wynand Alkema,

Pär G. Engström,

Wyeth W. Wasserman,

Boris Lenhard

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkh012

Subject(s) - biology , transcription factor , dna binding site , computational biology , genome , genetics , transcription (linguistics) , database , promoter , gene , computer science , gene expression , linguistics , philosophy

The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genome-wide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.

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