SPA: simple web tool to assess statistical significance of DNA patterns | Zendy

Hugues Richard | Zendy

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SPA: simple web tool to assess statistical significance of DNA patterns

Author(s) -

Hugues Richard

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkg613

Subject(s) - simple (philosophy) , statistic , biology , computer science , sequence (biology) , data mining , computation , computational biology , algorithm , bioinformatics , statistics , mathematics , genetics , philosophy , epistemology

Many statistical methods and programs are available to compute the significance of a given DNA pattern in a genome sequence. In this paper, after outlining the mathematical background of this problem, we present SPA (Statistic for PAtterns), an expert system with a simple web interface designed to be applied to two of these methods (large deviation approximations and exact computations using simple recurrences). A few results are presented, leading to a comparison between the two methods and to a simple decision rule in the choice of that to be used. Finally, future developments of SPA are discussed. This tool is available at the following address: http://stat.genopole.cnrs.fr/SPA/.

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