PARSESNP: a tool for the analysis of nucleotide polymorphisms | Zendy

Nicholas E. Taylor | Zendy; Elizabeth A. Greene | Zendy

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PARSESNP: a tool for the analysis of nucleotide polymorphisms

Author(s) -

Nicholas E. Taylor,

Elizabeth A. Greene

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkg574

Subject(s) - biology , genetics , intron , exon , gene , sequence analysis , missense mutation , computational biology , nucleic acid sequence , sequence alignment , dna sequencing , homology (biology) , peptide sequence , mutation

PARSESNP is a tool for the display and analysis of polymorphisms in genes. Using a reference DNA sequence, an exon/intron position model and a list of polymorphisms, it determines the effects of these polymorphisms on the expressed gene product, as well as the changes in restriction enzyme recognition sites. It shows the locations and effects of the polymorphisms in summary on a stylized graphic and in detail on a display of the protein sequence aligned with the DNA sequence. The addition of a homology model, in the form of an alignment of related protein sequences, allows for prediction of the severity of missense changes. PARSESNP is available on the World Wide Web at http://www.proweb.org/parsesnp/.

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