SIFT: predicting amino acid changes that affect protein function | Zendy

P.C. Ng | Zendy

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SIFT: predicting amino acid changes that affect protein function

Author(s) -

P.C. Ng

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkg509

Subject(s) - biology , scale invariant feature transform , amino acid , genetics , single nucleotide polymorphism , snp , mutagenesis , amino acid substitution , coding region , computational biology , gene , mutation , genotype , artificial intelligence , computer science , feature extraction

Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding regions. Each substitution has the potential to affect protein function. SIFT (Sorting Intolerant From Tolerant) is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study. We have shown that SIFT can distinguish between functionally neutral and deleterious amino acid changes in mutagenesis studies and on human polymorphisms. SIFT is available at http://blocks.fhcrc.org/sift/SIFT.html.

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