Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics | Zendy

John P. McCutcheon | Zendy

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Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics

Author(s) -

John P. McCutcheon

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkg438

Subject(s) - biology , saccharomyces cerevisiae , genomics , computational biology , identification (biology) , comparative genomics , genetics , computational genomics , genome , yeast , gene , botany

We screened for new structural non-coding RNAs (ncRNAs) in the genome sequence of the yeast Saccharomyces cerevisiae using computational comparative analysis of genome sequences from five related species of Saccharomyces. The screen identified 92 candidate ncRNA genes. Thirteen showed discrete transcripts when assayed by northern blot. Of these, eight appear to be novel ncRNAs ranging in size from 268 to 775 nt, including three new H/ACA box small nucleolar RNAs.

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