The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials | Zendy

Simon D Harding | Zendy; Jane F Armstrong | Zendy; Elena Faccenda | Zendy; Christopher Southan | Zendy; S P H Alexander | Zendy; Anthony P. Davenport | Zendy; Adam J Pawson | Zendy; Michael Spedding | Zendy; Jamie A. Davies | Zendy

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The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Author(s) -

Simon D Harding,

Jane F Armstrong,

Elena Faccenda,

Christopher Southan,

S P H Alexander,

Anthony P. Davenport,

Adam J Pawson,

Michael Spedding,

Jamie A. Davies

Publication year - 2021

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkab1010

Subject(s) - malaria , biology , pandemic , clinical pharmacology , pharmacology , covid-19 , medicine , immunology , infectious disease (medical specialty) , disease

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.

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