The effect of sequence specific DNA methylation on restriction endonuclease cleavage | Zendy

Michael McClelland | Zendy

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The effect of sequence specific DNA methylation on restriction endonuclease cleavage

Author(s) -

Michael McClelland

Publication year - 1981

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/9.22.5859

Subject(s) - biology , restriction enzyme , methylation , genetics , dna , cleavage (geology) , dna methylation , endonuclease , microbiology and biotechnology , isoschizomer , recognition sequence , gene , gene expression , paleontology , fracture (geology)

Sequence specific DNA methylation sometimes results in the protection of some or all of a restriction endonucleases' cleavage sites. This is usually, but not always, the result of methylation of one or both strands of DNA at the site characteristic of the corresponding "cognate" modification methylase. The known effects of sequence specific methylation on restriction endonucleases are compiled.

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