Homologous 3′-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei | Zendy

Hemanta K. Majumder | Zendy; John C. Boothroyd | Zendy; Hans Weber | Zendy

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Homologous 3′-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei

Author(s) -

Hemanta K. Majumder,

John C. Boothroyd,

Hans Weber

Publication year - 1981

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/9.18.4745

Subject(s) - biology , trypanosoma brucei , antigen , antigenic variation , genetics , trypanosoma , homologous chromosome , virology , gene , microbiology and biotechnology

Sequences corresponding to the complete 3'-terminal regions of the messenger RNAs for three different Variant Surface Glycoproteins of Trypanosoma brucei were determined on complementary DNA inserts cloned in recombinant plasmids. The three sequences show 80-130 base pair long segments of strong (70-80%) homology at the 3' ends, whereas ther regions upstream from the last 130-140 base pairs contain no significant homology. The signal AAUAAA, present near the 3' ends of almost all known polyadenylated mRNAs of eukaryotes, does not occur in the 3'-terminal sequences of these three variants.

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