Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymeiase α by aphidicolin | Zendy

Andrew M. Holmes | Zendy

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Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymeiase α by aphidicolin

Author(s) -

Andrew M. Holmes

Publication year - 1981

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/9.1.161

Subject(s) - aphidicolin , biology , dna , enzyme , dna polymerase , dna synthesis , microbiology and biotechnology , biochemistry , polymerase

On activated DNA aphidicolin competitively inhibits the incorporation of dCMP by both calf thymus DNA polymerase alpha A2 and C enzymes and inhibits the incorporation of the other three deoxynucleoside monophosphates apparently non-competitively. However, aphidicolin does not inhibit the incorporation of dAMP into poly(dT) . oligo(A)10 nor does it inhibit the incorporation of dGMP into poly(dC) . oligo(dG)10, but, it does competitively inhibit the incorporation of dTMP into poly(dA) . oligo(dT)10.

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