A route to RNA with an alkylating group at the 5′-triphosphate residue | Zendy

M.A. Grachev | Zendy; A.A. Mustaev | Zendy; S. I. Oshevski | Zendy

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A route to RNA with an alkylating group at the 5′-triphosphate residue

Author(s) -

M.A. Grachev,

A.A. Mustaev,

S. I. Oshevski

Publication year - 1980

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/8.15.3413

Subject(s) - biology , rna , residue (chemistry) , group (periodic table) , biochemistry , genetics , gene , organic chemistry , chemistry

Reaction of ATP with N,N,N'-tris(2-chloroethyl), N' (p-formyl-phenyl)propylenediamine-1,3 (abbreviation C13R) afforded a gamma-ester of ATP (abbreviation C1RpppA) - the product of alkylation by an aliphatic nitrogen mustard residue of C13R. The alkylating activity of the aromatic nitrogen mustard residue of C1RpppA is suppressed by the electron-acceptor effect of the p-formyl group. C1RpppA is a substrate of RNA-polymerase, and affords RNA with C1RpppA-residues at the 5'-termini.

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