Complete nucleotide suquence of the haemagglutinin gene from a human influenza virus of the Hong Kong subtype | Zendy

G W Both | Zendy; M.J. Sleigh | Zendy

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Complete nucleotide suquence of the haemagglutinin gene from a human influenza virus of the Hong Kong subtype

Author(s) -

G W Both,

M.J. Sleigh

Publication year - 1980

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/8.12.2561

Subject(s) - biology , virology , gene , virus , influenza a virus , nucleotide , genetics , human influenza , nucleic acid sequence , orthomyxoviridae , base sequence , covid-19 , infectious disease (medical specialty) , medicine , disease , pathology

The complete nucleotide sequence has been determined for a cloned double-stranded DNA copy of the haemagglutinin gene from the human influenza strain A/NT/60/68/29C, a laboratory-isolated variant of A/NT/60/68, an early strain of the Hong Kong subtype. The gene is 1765 nucleotides long and contains information sufficient to code for a protein of 566 amino acids, which includes a hydrophobic leader peptide (16 residues), HA1 (328), HA2 (221) and an arginine residue which joins the HA subunits. Comparison of the predicted amino acid sequence for 29C haemagglutinin with protein sequence data available for HA from other influenza strains shows that no potential coding information is lost by processing of the mRNA. A comparison of the amino acid sequences predicted from the gene sequences for 29C and fowl plague virus haemagglutinins, (1) indicates the extent to which changes can occur in the primary sequence of different regions of the protein, while maintaining essential structure and function.

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