The existence of DNA sequences homologous to adenovirus 5 DNA in the genome of normal rat cells | Zendy

Ella Frolova | Zendy; G. P. Georgiev | Zendy

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The existence of DNA sequences homologous to adenovirus 5 DNA in the genome of normal rat cells

Author(s) -

Ella Frolova,

G. P. Georgiev

Publication year - 1979

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/7.6.1419

Subject(s) - biology , adenovirus genome , genome , dna , homologous chromosome , nucleic acid thermodynamics , microbiology and biotechnology , virus , restriction enzyme , endonuclease , in vitro recombination , adenoviridae , virology , genetics , recombinant dna , gene , molecular cloning , complementary dna , base sequence

Three discrete bands specifically hybridizing to adenovirus 5 DNA were found in the rat liver DNA restricted BY Bam HI endonuclease and fractionated electrophoretically. The hybridization with different regions of the viral genome takes place. Similar bands are present in the DNA from different lines of adenovirus 5 transformed cells, but in these cases high molecular weight DNA fragments containing the integrated viral genomes can also be found.

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