Identification of a DNA polymerase β-like form in Drosophila melanogaster adult flies | Zendy

Maria Furia | Zendy; Lino C. Polito | Zendy; Giovanni Locorotondo | Zendy; P. Grippo | Zendy

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Identification of a DNA polymerase β-like form in Drosophila melanogaster adult flies

Author(s) -

Maria Furia,

Lino C. Polito,

Giovanni Locorotondo,

P. Grippo

Publication year - 1979

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/6.10.3399

Subject(s) - biology , drosophila melanogaster , dna polymerase , polymerase , drosophilidae , dna polymerase ii , dna , dna clamp , genetics , drosophila (subgenus) , polymerase chain reaction , microbiology and biotechnology , gene , reverse transcriptase

DNA polymerase beta is widely distributed in the eukariotes. So far, few examples are known in which a DNA polymerase alpha -like form alone is reported. Surprisingly, DNA polymerase beta was not detected in Drosophila embryos, while it is present in the cells of multicellular species from sponge to mammals. In view of the relevance of Drosophila as a model biological system for studying the role of the various DNA metabolism enzymes in vivo we have reinvestigated the presence of the DNA polymerase beta-like form in Drosophila adult flies. Here we report the occurrence in Drosophila melanogaster adult flies of a DNA polymerase activity that, for its NEM(1) resistance, template specificity, sensitivity to ddTTP, sedimentation coefficient and nuclear localization can be classified as a beta-like form.

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