Open AccessApurinic DNA endonuclease activities in repair-deficient human cell lines
Author(s) -
Robb E. Moses,
Arthur L. Beaudet
Publication year - 1978
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/5.2.463
Subject(s) - xeroderma pigmentosum , biology , cockayne syndrome , bloom syndrome , endonuclease , dna repair , ap site , ataxia telangiectasia , microbiology and biotechnology , nucleotide excision repair , dna , cell culture , genetics , dna damage , gene , helicase , rna
Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.
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