Open AccessPhotoproducts from DNA pyrimidine bases and polycyclic aromatic hydrocarbons
Author(s) -
G. Michael Blackburn,
Roger Fenwick,
G. Brian Lockwood,
Gary M. Williams
Publication year - 1977
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/4.7.2487
Subject(s) - thymine , pyrene , anthracene , pyrimidine , biology , dna , pyrimidine dimer , photochemistry , stereochemistry , biochemistry , chemistry , dna damage , astrobiology
The major photoproduct formed between benzo[a]pyrene and thymine is identified as 1-(benzo[a]pyren-6-yl)-thymine by means of spectroscopic analysis and isotopic syntheses. Irradiation of 1-methylcytosine hydrochloride and anthracene gives two isolable photoproducts of which one is assigned the structure 5-(anthracen-9-yl)-1-methylcytosine.
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