Interactions of Hg(II) ions with DNA as revealed by CD measurements | Zendy

Axel Walter | Zendy; G. Luck | Zendy

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Interactions of Hg(II) ions with DNA as revealed by CD measurements

Author(s) -

Axel Walter,

G. Luck

Publication year - 1977

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/4.3.539

Subject(s) - dna , circular dichroism , biology , ion , crystallography , microbiology and biotechnology , stereochemistry , biochemistry , chemistry , organic chemistry

The circular dichroism spectra of Hg(II) complexes with native calf thymus DNA, chemically methylated Streptomyces chrysomallus DNA and with Ag(I)-DNA complexes were measured in the region of 220 - 340 nm. As a main result a conversion of the conservative CD spectrum of DNA to a distinct nonconservative type of CD spectrum for the complexes occurs with increasing Hg(II) concentration. The CD spectra of the Hg(II) complexes as well as some additional arguments strongly support the idea, that DNA in the complex undergoes a structural transition to a more condensed state with 4 -like character.

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