Direct evidence that ribosome bound RNA-dependent RNA polymerase does not play a role in globin messenger RNA replication | Zendy

Charles D. Boyd | Zendy; W. Fitschen | Zendy

Open Access

Direct evidence that ribosome bound RNA-dependent RNA polymerase does not play a role in globin messenger RNA replication

Author(s) -

Charles D. Boyd,

W. Fitschen

Publication year - 1977

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/4.2.461

Subject(s) - biology , rna dependent rna polymerase , rna polymerase i , rna , five prime cap , polymerase , microbiology and biotechnology , messenger rna , globin , rna editing , ribosome , rna polymerase , small nuclear rna , dna , genetics , gene

The radioactively labelled product of RNA-dependent RNA polymerase+ from ribosomes of immature chicken erythrocytes was tested for the presence of newly replicated globin mRNA using unlabelled globin complementary DNA. No radioactively labelled globin mRNA sequences were found in the product, providing direct confirmation that this RNA-dependent RNA polymerase is not involved in globin mRNA amplification.

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