Levels of DNA polymerase -α and β in normal and xeroderma pigmentosum fibroblasts | Zendy

Umberto Bertazzonl | Zendy; Miria Stefanini | Zendy; Guido PedraliNoy | Zendy; Fiorella Nuzzo | Zendy; Arturo Falaschi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Levels of DNA polymerase -α and β in normal and xeroderma pigmentosum fibroblasts

Author(s) -

Umberto Bertazzonl,

Miria Stefanini,

Guido PedraliNoy,

Fiorella Nuzzo,

Arturo Falaschi

Publication year - 1977

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/4.1.141

Subject(s) - xeroderma pigmentosum , biology , dna polymerase , microbiology and biotechnology , polymerase , complementation , dna , genetics , dna repair , gene , mutant

We have determined the levels of DNA-polymerases-alpha and-beta in fibroblasts obtained from normal subjects and from patients with Xeroderma Pigmentosum (XP) belonging to three different complementation groups and to the variant form. The assays have been performed in crude extracts and after fractionation on sucrose gradients. The levels of alpha and beta-polymerases in the different cases of XP were found to lie within the same range as the control values, and no correlation was found with the severity of the symptoms. The sedimentation coefficients of the two polymerases from all the pathological lines were identical to those of the normal fibroblasts.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research