Natural and pharmacological regulation of telomerase | Zendy

JeanLouis Mergny | Zendy; JeanFrançois Riou | Zendy; Patrick Mailliet | Zendy; Mp. Teulade-Fichou | Zendy; Éric Gilson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Natural and pharmacological regulation of telomerase

Author(s) -

JeanLouis Mergny,

JeanFrançois Riou,

Patrick Mailliet,

Mp. Teulade-Fichou,

Éric Gilson

Publication year - 2002

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/30.4.839

Subject(s) - telomere , telomerase , biology , dna , somatic cell , eukaryotic chromosome fine structure , telomerase reverse transcriptase , reverse transcriptase , microbiology and biotechnology , cell division , telomerase rna component , genetics , cell , gene , rna

The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from 'broken' DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research