Tiny telomere DNA | Zendy

Jinsong Ren | Zendy

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Tiny telomere DNA

Author(s) -

Jinsong Ren

Publication year - 2002

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/30.11.2307

Subject(s) - biology , telomere , circular dichroism , dna , duplex (building) , g quadruplex , nucleic acid denaturation , computational biology , biophysics , gel electrophoresis , genetics , base sequence , biochemistry

We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex-quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.

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