Models of triple-stranded polynucleotides with optimised stereochemistry | Zendy

Struther Arnott | Zendy; Peter J. Bond | Zendy; Erik Selsing | Zendy; Paul J. Smith | Zendy

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Models of triple-stranded polynucleotides with optimised stereochemistry

Author(s) -

Struther Arnott,

Peter J. Bond,

Erik Selsing,

Paul J. Smith

Publication year - 1976

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/3.10.2459

Subject(s) - polynucleotide , hydrogen bond , crystallography , ring (chemistry) , materials science , stereochemistry , biology , molecule , chemistry , biochemistry , organic chemistry

Detailed models are presented for the triple-stranded polynucleotide helices of poly (U)-poly (A)-poly (U) (two forms), poly (U)-poly d (A) -poly (U), poly d(C)-poly d(I)-poly d(C), poly d(T)-polyd(A)-poly d(T) and poly (I)-poly (A)-poly (I). The models were genrated using a computerized, linked-atom procedure which preserves standard bond lengths, bond anglesand sugar ring conformations, constrains the helices to have the pitches and symmetries observed in X-ray diffraction experiments, and optimises the non-bonded interatomic contacts including hydrogen bonds. The possible biological sigificance of such complexes is discussed.

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