DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits | Zendy

D. R. Hewish | Zendy

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DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits

Author(s) -

D. R. Hewish

Publication year - 1976

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/3.1.69

Subject(s) - biology , eukaryotic dna replication , origin recognition complex , chromatin , dna replication , control of chromosome duplication , pre replication complex , genetics , origin of replication , histone , dna , base pair , microbiology and biotechnology , computational biology

A model is proposed whereby eukaryotic DNA replication is specifically directed by the 200 base pair repeat structure of the DNA-histone complex. The model proposes a mechanism for the sequential, bidirectional replication of DNA from initial origin points on the chromatin fibre and is consistent with the known properties of eukaryotic DNA replication. Several predictions can be made from the model which are amenable to testing.

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