Comparative analysis of FUR regulons in gamma-proteobacteria | Zendy

Ekaterina M. Panina | Zendy; Mironov AIu | Zendy; Mikhail S. Gelfand | Zendy

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Comparative analysis of FUR regulons in gamma-proteobacteria

Author(s) -

Ekaterina M. Panina,

Mironov AIu,

Mikhail S. Gelfand

Publication year - 2001

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/29.24.5195

Subject(s) - biology , yersinia pestis , regulon , virulence , vibrio cholerae , comparative genomics , salmonella typhi , yersinia , genetics , repressor , proteobacteria , microbiology and biotechnology , bacterial genome size , operon , pathogenicity island , genome , escherichia coli , genomics , bacteria , gene , 16s ribosomal rna , transcription factor

Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.

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