CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins | Zendy

Evgenia V. Kriventseva | Zendy

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CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins

Author(s) -

Evgenia V. Kriventseva

Publication year - 2001

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/29.1.33

Subject(s) - uniprot , biology , protein data bank (rcsb pdb) , computational biology , cluster analysis , structural classification of proteins database , hierarchical clustering , similarity (geometry) , protein domain , bioinformatics , protein structure , genetics , computer science , biochemistry , gene , machine learning , artificial intelligence , image (mathematics)

The CluSTr (Clusters of SWISS-PROT and TrEMBL proteins) database offers an automatic classification of SWISS-PROT and TrEMBL proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences. Analysis has been carried out for different levels of protein similarity, yielding a hierarchical organisation of clusters. The database provides links to InterPro, which integrates information on protein families, domains and functional sites from PROSITE, PRINTS, Pfam and ProDom. Links to the InterPro graphical interface allow users to see at a glance whether proteins from the cluster share particular functional sites. CluSTr also provides cross-references to HSSP and PDB. The database is available for querying and browsing at http://www.ebi.ac.uk/clustr.

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