Misincorporation of 2'-deoxyoxanosine into DNA: a molecular basis for NO-induced mutagenesis derived from theoretical calculations | Zendy

Belén Hernández | Zendy

Open Access

Misincorporation of 2'-deoxyoxanosine into DNA: a molecular basis for NO-induced mutagenesis derived from theoretical calculations

Author(s) -

Belén Hernández

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.24.4873

Subject(s) - guanine , thymine , tautomer , cytosine , dna , biology , mutagenesis , nucleobase , molecular dynamics , aqueous solution , gas phase , ab initio , computational chemistry , chemical physics , thermodynamics , mutation , genetics , stereochemistry , chemistry , nucleotide , physics , gene , organic chemistry

A wide range of theoretical methods, including high level ab initio, density functional, self-consistent reaction field, molecular dynamics and thermodynamic integration calculations, have been used to analyze the mutagenic properties of oxanosine. The major tautomeric forms in the gas phase and aqueous solution have been determined. The ability of oxanosine to recognize thymine and cytosine in the gas phase and in the DNA environment has been compared with that of guanine. A physicochemical explanation for the mutagenic properties of oxanosine is suggested.

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