SURVEY AND SUMMARY: From DNA biosensors to gene chips | Zendy

J. Wang | Zendy

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SURVEY AND SUMMARY: From DNA biosensors to gene chips

Author(s) -

J. Wang

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.16.3011

Subject(s) - biosensor , biology , dna , dna–dna hybridization , computational biology , dna microarray , gene , hybridization probe , nanotechnology , genetics , gene expression , materials science , biochemistry

Wide-scale DNA testing requires the development of small, fast and easy-to-use devices. This article describes the preparation, operation and applications of biosensors and gene chips, which provide fast, sensitive and selective detection of DNA hybridization. Various new strategies for DNA biosensors and gene chips are examined, along with recent trends and future directions. The integration of hybridization detection schemes with the sample preparation process in a 'Lab-on-a-Chip' format is also covered. While the use of DNA biosensors and gene chips is at an early stage, such devices are expected to have an enormous effect on future DNA diagnostics.

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