KinMutBase, a database of human disease-causing protein kinase mutations | Zendy

Katariina Stenberg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

KinMutBase, a database of human disease-causing protein kinase mutations

Author(s) -

Katariina Stenberg

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.1.369

Subject(s) - biology , kinase , protein serine threonine kinases , serine , mutation , threonine , genetics , sh3 domain , tyrosine kinase , phosphorylation , mitogen activated protein kinase , receptor tyrosine kinase , protein kinase a , signal transduction , gene

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases. There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations and changes to restriction enzyme patterns.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research