SCOP: a Structural Classification of Proteins database | Zendy

Loredana Lo Conte | Zendy; Bart Ailey | Zendy; Tim Hubbard | Zendy; Steven E. Brenner | Zendy; Alexey G. Murzin | Zendy; C. Chothia | Zendy

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SCOP: a Structural Classification of Proteins database

Author(s) -

Loredana Lo Conte,

Bart Ailey,

Tim Hubbard,

Steven E. Brenner,

Alexey G. Murzin,

C. Chothia

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.1.257

Subject(s) - structural classification of proteins database , protein data bank (rcsb pdb) , biology , pairwise comparison , protein structure database , protein superfamily , protein data bank , sequence alignment , protein family , database , sequence database , computational biology , sequence (biology) , feature (linguistics) , protein structure , protein evolution , information retrieval , genetics , peptide sequence , computer science , artificial intelligence , biochemistry , gene , linguistics , philosophy

The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of known protein structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and distant evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary relationships and those that arise from the physics and chemistry of proteins is a feature that is unique to this database so far. The sequences of proteins in SCOP provide the basis of the ASTRAL sequence libraries that can be used as a source of data to calibrate sequence search algorithms and for the generation of statistics on, or selections of, protein structures. Links can be made from SCOP to PDB-ISL: a library containing sequences homologous to proteins of known structure. Sequences of proteins of unknown structure can be matched to distantly related proteins of known structure by using pairwise sequence comparison methods to find homologues in PDB-ISL. The database and its associated files are freely accessible from a number of WWW sites mirrored from URL http://scop.mrc-lmb.cam.ac.uk/scop/

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