SMART: a web-based tool for the study of genetically mobile domains | Zendy

J. Schultz | Zendy

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SMART: a web-based tool for the study of genetically mobile domains

Author(s) -

J. Schultz

Publication year - 2000

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/28.1.231

Subject(s) - biology , phyletic gradualism , modular design , computational biology , domain (mathematical analysis) , annotation , identification (biology) , protein domain , database , bioinformatics , computer science , genetics , phylogenetics , gene , programming language , mathematical analysis , botany , mathematics

SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.

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