Proximal transcribed regions of bacterial promoters have a non-random distribution of A/T tracts | Zendy

Olga N. Ozoline | Zendy; Vitaly Chasov | Zendy; А. Д. Деев | Zendy; M.V. Arkhipova | Zendy; A. Travers | Zendy

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Proximal transcribed regions of bacterial promoters have a non-random distribution of A/T tracts

Author(s) -

Olga N. Ozoline,

Vitaly Chasov,

А. Д. Деев,

M.V. Arkhipova,

A. Travers

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.24.4768

Subject(s) - biology , promoter , rna polymerase , transcription (linguistics) , genetics , escherichia coli , microbiology and biotechnology , gene , gene expression , linguistics , philosophy

Promoter sequences of Escherichia coli were compiled and their transcribed regions characterized by site-specific cluster analysis. Here we report that transcribed regions contain a non-random distribution of A/T tracts with strongly preferred positions at 6 +/- 3, 23 +/- 3, 40 +/- 2 and 56 +/- 2. The maxima of this distribution follow an unusual periodicity (approximately 17 bp) and are in phase with important promoter elements involved in interaction with RNA polymerase, while the value of periodicity numerically fits the spacer length between the canonical -35 and -10 elements. The possible functional significance of this newly described feature is discussed in the context of promoter clearance and transcription pausing.

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