Compilation and analysis of 54-dependent promoter sequences | Zendy

Hernando Barrios Tao | Zendy; Brenda Valderrama | Zendy; Enrique Morett | Zendy

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Compilation and analysis of 54-dependent promoter sequences

Author(s) -

Hernando Barrios Tao,

Brenda Valderrama,

Enrique Morett

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.22.4305

Subject(s) - biology , promoter , consensus sequence , genetics , rna polymerase , sigma factor , polymerase , rna polymerase ii , sequence (biology) , computational biology , base sequence , rna , microbiology and biotechnology , dna , gene , gene expression

Promoters recognized by the RNA-polymerase with the alternative sigma factor sigma(54) (Esigma54) are unique in having conserved positions around -24 and -12 nucleotides upstream from the transcriptional start site, instead of the typical -35 and -10 boxes. Here we compile 186 -24/-12 promoter sequences reported in the literature and generate an updated and extended consensus sequence. The use of the extended consensus increases the probability of identifying genuine -24/-12 promoters. The effect of several reported mutations at the -24/-12 elements on RNA-polymerase binding and promoter strength is discussed in the light of the updated consensus.

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