Open AccessDNAPROBE, a computer program which generates oligonucleotide probes from protein alignments
Author(s) -
Martin Drummond,
J. G. Stamper
Publication year - 1999
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/27.17.3493
Subject(s) - biology , oligonucleotide , computational biology , genetics , oligomer restriction , dna
We describe a program to assist in designing oligonucleotide probes on the basis of protein alignments and the codon usage of the target organism. If necessary, the input sequences can be weighted to neutralise the effect of closely similar sequences or to bias the output in favour of a particular taxon.
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