Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade | Zendy

Y.-Z. Liu | Zendy; L M Boxer | Zendy; D.S. Latchman | Zendy

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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

Author(s) -

Y.-Z. Liu,

L M Boxer,

D.S. Latchman

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.10.2086

Subject(s) - biology , nerve growth factor , cascade , mapk cascade , mapk/erk pathway , microbiology and biotechnology , neuroscience , genetics , signal transduction , receptor , chemistry , chromatography

The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.

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