RegulonDB (version 2.0): a database on transcriptional regulation in Escherichia coli | Zendy

H. Salgado | Zendy; A. Santos | Zendy; U. Garza-Ramos | Zendy; Jacques van Helden | Zendy; Elva Dı́az | Zendy; Julio ColladoVides | Zendy

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RegulonDB (version 2.0): a database on transcriptional regulation in Escherichia coli

Author(s) -

H. Salgado,

A. Santos,

U. Garza-Ramos,

Jacques van Helden,

Elva Dı́az,

Julio ColladoVides

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.1.59

Subject(s) - operon , regulon , biology , escherichia coli , hypertext , genome , genetics , database , gene , computational biology , world wide web , computer science

RegulonDB version 2.0, a database on transcriptional regulation and operon organization in Escherichia coli, is now available on the web at the following URL: http://www.cifn.unam. mx/Computational_Biology/regulondb/. In this paper we describe the main computational changes to the database, which include migrating the database to Sybase, providing graphical descriptions of the internal organization of operons and regulons, and direct links to MEDLINE references. The web interface offers searching either by mechanisms of regulation or by operon organization. The results of a search (operon organization, or site collection) are displayed as hypertext, and can also be displayed graphically. In terms of its contents, RegulonDB contains a large number of operons, as well as the absolute position in the completed genome sequence of sites, promoters, and individual genes of E.coli.

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