The ligand gated ion channel database | Zendy

Nicolas Le Novère | Zendy; J P Changeux | Zendy

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The ligand gated ion channel database

Author(s) -

Nicolas Le Novère,

J P Changeux

Publication year - 1999

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/27.1.340

Subject(s) - biology , ionotropic effect , ion channel , database , nucleic acid , ligand gated ion channel , protein subunit , sequence database , computational biology , receptor , bioinformatics , biochemistry , glutamate receptor , computer science , gene

The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits. A database has been developed to handle the growing wealth of cloned subunits. This database contains nucleic acid sequences, protein sequences, as well as multiple sequence alignments and phylogenetic studies. This database is accessible via the worldwide web (http://www.pasteur.fr/units/neubiomol/LGIC.h tml), where it is continuously updated. A downloadable version is also available [currently v0.1 (98.06)].

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